CoQ10 Supplementation in Male Factor Infertility: Benefits, Dosage, and Evidence

May 06, 2023

Coenzyme Q10, or CoQ10, is a naturally occurring enzyme found in every cell in the human body. It plays an important role in the production of energy within cells and acts as a powerful antioxidant. Studies have shown that CoQ10 supplements can also improve male fertility by increasing sperm count, motility, and overall quality.

One of the main factors that can impact male fertility is oxidative stress, which occurs when there is an imbalance between the production of harmful free radicals and the body's ability to neutralize them with antioxidants. This can lead to DNA damage in sperm cells, resulting in decreased sperm count, poor motility, and abnormal morphology. CoQ10 can help combat oxidative stress by neutralizing free radicals and protecting sperm from damage.

Several studies have found that CoQ10 supplementation can improve sperm quality and quantity. In a 2013 study published in the journal Andrologia, researchers found that men with low sperm count who took CoQ10 supplements for six months saw significant improvements in sperm count, motility, and morphology. Another study published in the journal Fertility and Sterility found that CoQ10 supplementation improved sperm motility and fertilization rates in men with unexplained infertility.

So what is the recommended dosage of CoQ10 for male fertility? The optimal dosage varies depending on the individual and their specific needs, but most studies have used dosages ranging from 100-300mg per day. It is important to speak with a healthcare professional before starting CoQ10 or any new supplement regimen.

Thank you for reading.

Dr. Tamara

References:

• Safarinejad MR. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. Int Urol Nephrol. 2012;44(3):689-700.
• Balercia G, Mosca F, Mantero F, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004;81(1):93-98.
• Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol. 2009;182(1):237-248.
• Safarinejad MR. Effect of Coenzyme Q10 Supplementation on Semen Parameters and Oxidative Stress in Men With Idiopathic Infertility. Urol J. 2019;16(6):610-614.
• Mancini A, Balercia G. Coenzyme Q(10) in male infertility: physiopathology and therapy. Biofactors. 2011;37(5):374-380.

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